Browsing articles in "Addiction/Reward"


FDA Warns Orally Dissolving Buprenorphine Tied to Dental Problems
January 12, 2022   

The U.S. Food and Drug Administration is warning that dental problems have been reported with medicines containing buprenorphine that are dissolved in the mouth. The dental problems, including tooth decay, cavities, oral infections, and loss of teeth, can be serious and have been reported even in patients with no history of dental issues...
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2021 NEI Congress Recreational Drug Use Workshop
November 4, 2021   

The 2021 NEI Congress kicked off with a pre-conference workshop on recreational drugs—both as illicit agents and as potential therapeutic options. Roger S. McIntyre, MD, FRCPC began the workshop with “An Update on Psychedelics,” explaining both the historical use of these agents as therapeutic entities as well as the scientific rationale for the renewed interest in psychedelic-assisted therapy as a treatment paradigm. At present...
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Methamphetamine Use, Overdose Deaths From Psychostimulants Are Increasing
October 14, 2021   

It is estimated that from 2015 to 2019, the number of overdose deaths from psychostimulants other than cocaine (namely methamphetamines) has more than doubled. In this cross-sectional study involving nearly 200,000 individuals aged 18-64, the authors sought to uncover some of the factors associated with this increase in overdose deaths from methamphetamines...
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Effects of Gabapentin With Abstinence in Alcohol Use Disorder
August 18, 2021   

Gabapentin blocks calcium channels containing the alpha 2 delta 1 subunit and has other actions that may affect both glutamatergic and GABAergic neurotransmission, much the same as drinking alcohol does. It is FDA-approved for the treatment of neuralgia, partial seizures, and restless legs syndrome; however, recent studies are investigating gabapentin as a potential medication for mitigating withdrawal and preventing relapse in alcohol use disorder...
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Slow-Release Oral Morphine May Help Patients With OUD
July 23, 2021   

Opioid use disorder (OUD), including use of both heroin and prescription opioids, is a problem of great concern across the globe. Treatments with the greatest promise include medication assisted therapies whereby an individual is treated with an opioid agonist (such as methadone), partial antagonist (such as buprenorphine), or antagonist (such as naltrexone). Additionally...
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Association of Cannabis Use During Adolescence With Neurodevelopment
July 6, 2021   

The association between cannabis use and adolescent neurodevelopment is not well characterized longitudinally. Data from the IMAGEN study, a community-based cohort study conducted across eight sites in western Europe, was used to examine the association between cerebral cortical thickness and cannabis use in mid to late adolescence. Participants...
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HHS Announces $3 Billion In Funds For Mental Health And Substance Abuse Block Grants
May 19, 2021   

The U.S. Department of Health and Human Services announces $3 billion in American Rescue Plan Funding for Substance Abuse and Mental Health Services Administration Block Grants to address mental health and substance abuse. This is the largest aggregate amount of funding to date for....
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FDA Approves Higher Dosage of Naloxone Nasal Spray to Treat Opioid Overdose
April 30, 2021   

The US Food and Drug Administration has approved Kloxxado (naloxone hydrochloride) nasal spray 8mg for its emergency treatment of known or suspected opioid overdose...
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PsychopharmaStahlogy Show: Psychedelic Assisted Psychotherapy
March 30, 2021   

The PsychopharmaStahlogy Show is a special podcast series released on the NEI Podcast. In the first three part series, Dr. Andrew Cutler asks Dr. Stephen Stahl important questions relating to psychedelic assisted psychotherapy as a novel approach to the treatment of psychiatric disorders...
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Methamphetamine Overdose Deaths in the US by Sex and Race and Ethnicity
February 17, 2021   

Rates of drug overdose involving methamphetamine have increased tremendously in the past decade. Work by Han and colleagues explored the extent to which methamphetamine overdose death rates in the United States (US) differed as a function of sex, race, and ethnicity using...
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