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    Medication Tips and Pearls

    Methylphenidate Formulations

    October 22, 2025
    Methylphenidate Formulations
    Methylphenidate (d) Formulations
    Formulation Brand Names Duration Dosing Approval
    Immediate-release tablet Focalin 4–6 hours, early peak 2nd dose at lunch Ages 6 to 17
    Extended-release capsule Focalin XR 8–10 hours, two peaks (after 1.5 and 6.5 hours) Once-daily in the morning Ages 6 and older
    Serdexmethylphenidate/ dexmethylphenidate capsule Azstarys Up to 10 hours Once-daily in the morning Ages 6 and older
     
    Methylphenidate (d, l) Formulations
    Formulation Brand Names Duration Dosing Approval
    Immediate-release tablet Ritalin 3–4 hours, early peak 2nd dose at lunch Ages 6 to 12 and adults
    Immediate-release oral solution Methylin 3–4 hours, early peak 2nd dose at lunch Ages 6 to 12 and adults
    Extended-release tablet Methylin ER 3–8 hours, early peak May need lunch dose Ages 6 and older
    Extended-release tablet Concerta 12 hours, small early peak Once-daily in the morning Ages 6 and older
    Extended-release tablet Relexxii Two peaks (at 1.5- and 5.5-hrs) Once-daily in the morning Ages 6 and older
    Extended-release chewable tablet QuilliChew ER 8 hours, peak at 5 hours Once-daily in the morning Ages 6 and older
    Extended-release capsule Metadate CD 8 hours, strong early peak Once-daily in the morning Ages 6 to 17
    Extended-release capsule Ritalin LA 6–8 hours, two strong peaks (early and at 4 hours) Once-daily in the morning Age 6 to 12
    Extended-release capsule Aptensio XR Up to 12 hours Once-daily in the morning Ages 6 and older
    Extended-release oral suspension Quillivant XR 12 hours, peak at 5 hours Once-daily in the morning Ages 6 and older
    Extended-release transdermal patch Daytrana 12 hours, peak at 7–10 hours Once-daily in the morning Ages 6 to 17
    Orally disintegrating tablet Cotempla XR-ODT 12 hours Once-daily in the morning Ages 6 to 17
    Extended-release capsule Jornay PM Initial absorption delayed by 10 hours, single peak at 14 hours Once-daily in the evening Ages 6 and older

    Related Practice Resources
    Medication Tips and Pearls
    Dose Equivalence: Methylphenidate Formulations
    Treatment Algorithms
    Pediatric ADHD
    Patient Education
    Treatment and Testing Guides: Stimulants for Children

    Adapted from NEI Prescribe. Copyright © Neuroscience Education Institute. The information in this site is constantly subject to scientific research and information may change.
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