US FDA Approvals for Serotonergic "Antidepressants"

October 22, 2025

	MDD	TRD	BD	PMDD	GAD	PD	SAD	PTSD	OCD	Other
citalopram (Celexa)
desvenlafaxine (Pristiq)
duloxetine (Cymbalta)					*					Diabetic peripheral neuropathy Fibromyalgia Chronic musculoskeletal pain
escitalopram (Lexapro)	*				*
fluoxetine (Prozac)	*	**	*^,**						*	Bulimia
fluvoxamine (Luvox)									*
levomilnacipran (Fetzima)
paroxetine (Paxil)										Vasomotor symptoms
sertraline (Zoloft)
venlafaxine (Effexor XR)										Separation anxiety disorder
vilazodone (Viibryd)
vortioxetine (Trintellix)

*Also in children

**With olanzapine

MDD: major depressive disorder. TRD: treatment-resistant depression. BD: bipolar depression. PMDD: premenstrual dysphoric disorder. GAD: generalized anxiety disorder. PD: panic disorder. SAD: social anxiety disorder. PTSD: posttraumatic stress disorder. OCD: obsessive compulsive disorder.

Related Practice Resources
	Screening and Diagnosis Anxiety, Mood, and Other Disorders
	Treatment Algorithms Pediatric Anxiety
	Treatment Algorithms Pediatric Major Depressive Disorder
	Switching and Deprescribing Switching Between Serotonergic "Antidepressants"
	Patient Education Medication Guides: Serotonergic "Antidepressants"
	Patient Education Treatment and Testing Guides: SSRIs for Teens

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