Browsing articles in "Unipolar Depression"


Novel Biomarker May Predict Patient Response to Antidepressants
January 16, 2022   

A pilot study evaluated the utility of a putative peripheral biomarker for depression and antidepressant treatment response. In depression, the heterotrimeric G protein Gsalpha is sequestered in lipid rafts, which leads to a reduction in adenylyl cyclase. Antidepressant treatment may translocate...
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Paternal Prevalence of Comorbid Depression and Anxiety During First Two Years Postpartum
January 4, 2022   

A recent longitudinally cohort study examined the prevalence of paternal comorbid depression and anxiety during the first and second year postpartum and investigated the predictors for comorbidity during the first and second-year following birth...
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Low Thyroid Hormone Levels Linked to Poorer Response to Depression Treatment
December 16, 2021   

Thyroid hormone changes are central to leading paradigms of depression; however, the ability of thyroid hormones to predict clinical outcomes of depression is still unclear. A study by Qiao and colleagues examined the predictive power of pretreatment free triiodothyronine, free thyroxine, and thyroid stimulating hormone to explain posttreatment response variability in patients..
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Postpartum Anhedonia: Emergent Patterns in Bipolar and Unipolar Depression
December 7, 2021   

Anhedonia, the lack of interest in previously pleasurable activities, is sometimes a symptom of depression and has been associate with worse outcomes. In this study, Gollan and colleagues looked at anhedonia in postpartum women with either unipolar postpartum depression...
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Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants
December 3, 2021   

There is some evidence indicating that mental illness, including depression and anxiety, may put COVID-19 patients at increased risk of serious illness and death. However, this study sought to find the relationship between taking a serotonin reuptake inhibitor...
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Brain Rhythm Predicts Response to DBS for Severe Depression
November 24, 2021   

Deep brain stimulation of the subcallosal cingulate may be a promising intervention for treatment-resistant depression. While one clinical file failed, multiple case series have reported positive results, especially since surgical procedures for it have improved. Recent evidence suggests that...
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Psilocybin Therapy Increases Cognitive And Neural Flexibility In Patients With Major Depressive Disorder
November 18, 2021   

Psilocybin therapy has shown promise in treating major depressive disorder and other psychiatric illnesses. However, the cognitive and neural mechanisms underlying its enduring efficacy is poorly understood. An open-label study examined the enduring effects of psilocybin therapy on the cognitive and neural flexibility...
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2021 NEI Congress Young Investigator Poster Competition Winners
November 5, 2021   

The 2021 NEI Congress Scientific Poster Session and Reception was held on Friday, November 5th and featured 67 posters, with an additional 48 posters presented virtually, covering the full spectrum of mental health research and clinical data. Among them, three particularly stood out for the quality of their data and contributions to the field, and...
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2021 NEI Congress Recreational Drug Use Workshop
November 4, 2021   

The 2021 NEI Congress kicked off with a pre-conference workshop on recreational drugs—both as illicit agents and as potential therapeutic options. Roger S. McIntyre, MD, FRCPC began the workshop with “An Update on Psychedelics,” explaining both the historical use of these agents as therapeutic entities as well as the scientific rationale for the renewed interest in psychedelic-assisted therapy as a treatment paradigm. At present...
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Insulin Resistance Linked to Major Depressive Disorder
October 7, 2021   

Major depressive disorder is often difficult to predict yet is the leading cause of disability worldwide. A growing body of literature suggests that metabolic parameters may influence the development or worsening of depression. In this longitudinal study of nearly...
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