Browsing articles in "Unipolar Depression"


Psychological Intervention During Tapering Of Antidepressant Medication May Be Alternative To Maintenance Monotherapy To Prevent Relapse
June 6, 2021   

Clinical guidelines recommend at least two years of antidepressant maintenance after remission from depression for patients at high risk of relapse. However, psychological intervention while undergoing tapering of antidepressant medication may be an alternative to long-term antidepressant use. A meta-analysis of randomized controlled trials...
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Psilocybin As Effective As Escitalopram At Reducing Depression
May 7, 2021   

Several studies have reported that psilocybin has antidepressant properties, however direct comparisons between established depression treatments and psilocybin are lacking. In a phase 2, double-blind randomized controlled trial included patients with long-term, moderate-to-severe major depressive disorder, over a six-week period. Patients were randomly...
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Mood Disorder Patients Experience Seasonal Changes In Varying Degrees
April 22, 2021   

Seasonal affective disorder is defined as depression that occurs with seasonality -typically occurring in the autumn and winter months and remitting in spring and summer. It is thought to be pathophysiologically related to circadian misalignment and can often be effectively treated, or even prevented, with light therapy and/or bupropion. Given that...
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Guidelines For The Use Of Ketamine For Treatment-Resistant Depression
April 12, 2021   

An international expert opinion on the use of ketamine for treatment-resistant depression was recently published. Although the various formulations of ketamine have not been compared directly in randomized controlled trials, intranasal esketamine and intravenous ketamine have the strongest evidence of short-term efficacy and safety in patients with ..
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Disturbed Sleep and Depression in Children and Youths
April 9, 2021   

In a recently published meta-analysis, the relationship between disturbed sleep and depression was examined. A total of 22 studies were included in the study, of which 16 were included in the meta-analysis. Disturbed sleep was...
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PsychopharmaStahlogy Show: Psychedelic Assisted Psychotherapy
March 30, 2021   

The PsychopharmaStahlogy Show is a special podcast series released on the NEI Podcast. In the first three part series, Dr. Andrew Cutler asks Dr. Stephen Stahl important questions relating to psychedelic assisted psychotherapy as a novel approach to the treatment of psychiatric disorders...
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Ketamine for Adolescents With Treatment-Resistant Depression
March 23, 2021   

The glutamatergic agent, ketamine, has been increasingly studied and shown to have great benefit in adults with major depressive disorder but has not been as thoroughly examined in children and adolescents. In this study...
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Aggression Reactivity in Depression May Signal Risk for Converting to Bipolar Disorder
February 20, 2021   

Identifying factors that predict conversion from depression to bipolar disorder may be useful for early recognition and appropriate treatment of bipolar disorder. The current study examined 1) whether anger, measured cross-sectionally, differed in patients who converted to bipolar disorder compared to patients with remitted or current unipolar depression; and..
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Scale May Detect More Than Depression in Early Pregnancy
February 8, 2021   

Postpartum depression continues to be prevalent, while early detection methods can help prevent this mental health condition. In a recent study, 2,271 antenatal women participated in a study that tested the efficacy of the Edinburgh Postnatal Depression Scale...
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Children With Congenital Heart Disease at Elevated Risk of Depression, Anxiety, ADHD
January 26, 2021   

A recent comparative cross-sectional study was conducted to examine the risk of mental health disorders (e.g. depression, anxiety, and attention deficit/hyperactivity disorder) in youth with congenital heart disease (CHD). Data was collected from...
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