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Olanzapine/Samidorphan Combo Found to Reduce Antipsychotic-Induced Weight Gain
September 1, 2020
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The combination of olanzapine, a dopamine D2 receptor antagonist, and samidorphan, an opioid receptor antagonist, is being developed for the treatment of schizophrenia and bipolar I disorder. Despite its efficacy, olanzapine is associated with significant weight gain and adverse metabolic effects that limit its clinical utility as a monotherapy. The combination of olanzapine and samidorphan has been shown to... |
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NEI Virtual Poster Library is Live!
July 13, 2020
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NEI has launched a Virtual Poster Library to fulfill the needs of poster presenters who had hoped to share their research and findings at medical conferences that have been cancelled due to the COVID-19 pandemic.... |
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Consensus Statement on Use of Antipsychotic Blood Levels
June 23, 2020
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It has been known that the quantification of antipsychotic levels in blood, known as therapeutic monitoring can be helpful in determining appropriate therapeutic dosing, and augmentation for treatment. It can be a useful tool for antipsychotics to manage challenging clinical scenarios, such as lack of therapeutic response, relapse, or adverse drug reactions (ADRs) related to antipsychotic treatment, especially... |
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Severe Clinical Consequences of Childhood Abuse and Neglect
February 10, 2020
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l infarction, cerebrovascular disease, type 2 diabetes, asthma, cancer, and overall lowered life expectancy. In this article, the authors review the current state of research regarding the association of early childhood abuse/neglect with development of psychiatric illness, particularly mood disorders such as... |
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Predicting Bipolar Disorder
October 11, 2019
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The International Society of Bipolar Disorders (ISBD) task force has recently published work attempting to identify some of the precursors and prodromes that may predict eventual diagnosis of bipolar disorder... |
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Age and Mixed Features May Predict Next-Step Strategies for Depression Remission
May 25, 2019
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Approximately 2/3 of patients with major depressive disorder (MDD) do not achieve remission despite adequate treatment with an antidepressant. It would be of utmost benefit to clinicians to be able to predict which patients would do better with which specific next-step treatment strategies -whether it be switching to a different antidepressant, combination of two antidepressants, or augmentation with a psychotropic from another drug class -rather than relying on trial and error... |
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