Browsing articles in "Basic Neuroscience"


Neural Circuits Of Anxiolytic And Antidepressant Pherine Molecules
March 16, 2022   

Pherines are a novel class of synthetic neuroactive steroids formulated to engage human nasal chemosensory receptors. They are administered intranasally and detected by olfactory afferents wired directly to the limbic amygdala. Due to this mechanism, they have rapid and potent effects on behavior and the autonomic nervous system...
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Brain Awareness Week 2022
March 14, 2022   

Each March, we observe Brain Awareness Week. Brain Awareness Week is the global campaign to foster public enthusiasm and support for brain science. Taking place this year March 14-20, 2022, Brain Awareness Week aims at advancing public awareness about the brain and brain research...
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Brain Rhythm Predicts Response to DBS for Severe Depression
November 24, 2021   

Deep brain stimulation of the subcallosal cingulate may be a promising intervention for treatment-resistant depression. While one clinical file failed, multiple case series have reported positive results, especially since surgical procedures for it have improved. Recent evidence suggests that...
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Psilocybin Therapy Increases Cognitive And Neural Flexibility In Patients With Major Depressive Disorder
November 18, 2021   

Psilocybin therapy has shown promise in treating major depressive disorder and other psychiatric illnesses. However, the cognitive and neural mechanisms underlying its enduring efficacy is poorly understood. An open-label study examined the enduring effects of psilocybin therapy on the cognitive and neural flexibility...
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2021 NEI Congress Young Investigator Poster Competition Winners
November 5, 2021   

The 2021 NEI Congress Scientific Poster Session and Reception was held on Friday, November 5th and featured 67 posters, with an additional 48 posters presented virtually, covering the full spectrum of mental health research and clinical data. Among them, three particularly stood out for the quality of their data and contributions to the field, and...
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5-HT4-Receptor Agonists May Boost Cognitive Impairments Associated With Psychiatric Disorders
October 25, 2021   

Many psychiatric disorders include symptoms of cognitive impairment, which has been challenging to treat. Mounting evidence from animal studies suggest that the 5-HT4 receptor could be a promising potential treatment target for cognitive impairment because...
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Do Psychiatric Disorders Present With Distinct or Shared Gut Microbial Alterations?
October 4, 2021   

Several lines of evidence suggest an involvement of the gut microbiota in the pathophysiology of psychiatric disorders, albeit with contradictory results. A review and meta-analysis of studies examining alpha and beta diversity and relative abundance of gut microbes in adult psychiatric populations...
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Association of Cannabis Use During Adolescence With Neurodevelopment
July 6, 2021   

The association between cannabis use and adolescent neurodevelopment is not well characterized longitudinally. Data from the IMAGEN study, a community-based cohort study conducted across eight sites in western Europe, was used to examine the association between cerebral cortical thickness and cannabis use in mid to late adolescence. Participants...
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Retraction of JAMA Study Regarding Link Between Autism and Male Brain
April 22, 2019   

An article published in JAMA Psychiatry back in 2017, has issued a notice of retraction and replacement on a study that claimed to find a link between typical male brain anatomy and autism...
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Evidence for Neuroprogression in Untreated Depression: Microglial Activation
March 23, 2018   

New brain imaging research from the Centre for Addiction and Mental Health (CAMH) shows that the brain alters after years of persistent depression...
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