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PSYCHOPHARMACOLOGY
Browsing articles in "Alzheimer's/Other Dementias"

 

Short Sleep Tied to Increased Dementia Risk
May 4, 2021   

In a recent study, the association between sleep dysregulation and dementia was examined. Data from 7,959 participants of the Whitehall II study was analyzed for sleep duration and the incidence of dementia, using a 25-year follow-up. A total of...
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Psychotropic Polypharmacy Prevalent in Patients With Dementia
March 25, 2021   

Dementia is increasingly prevalent as the population ages. In addition to memory deficits, patients with dementia often exhibit other neuropsychiatric symptoms that can be disturbing to caregivers and increase the likelihood of institutionalization. It is therefore not uncommon for patients with dementia to be prescribed psychotropic agents despite...
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Apathy an Early Marker of Frontotemporal Dementia
February 1, 2021   

Frontotemporal dementia is a disorder resulting from accumulation of pathological proteins such as phosphorylated tau and transactive response DNA binding protein of 43 kDA in the brain. Mutations in various genes, including microtubule associated protein tau...
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Systolic Orthostatic Hypotension Tied to Dementia Risk
August 21, 2020   

A recent study examined whether orthostatic hypotension and visit-to-visit blood pressure postural changes variability are associated with incident dementia. The study involved 2,131 people aged 73 years old on average. Repeatedly over a period of five years, researchers A recent study examined whether orthostatic hypotension and visit-to-visit blood pressure postural changes variability are associated with incident dementia. The study involved 2,131 people aged 73 years old on average. Over a period of five years, researchers...
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Biogen Submits Application for US Approval for Alzheimer Drug
July 27, 2020   

Biogen completed the submission of a Biologics License Application for its monoclonal antibody aducanumab to the US Food and Drug Administration for the treatment of Alzheimer’s disease...
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FDA Approves First Drug to Image Tau Pathology in Patients Being Evaluated for Alzheimer’s Disease
June 15, 2020   

The US Food and Drug Administration has approved flortaucipir F18 injection, a diagnostic agent for adult patients with cognitive impairment who are being evaluated for Alzheimer’s disease ...
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Use of Benzodiazepines or Z-drugs Not Associated With Subsequent Dementia
May 19, 2020   

Benzodiazepines and Z-drugs are indicated for treatment of affective disorders and insomnia. Due to cognitive side effects of these treatments, their use has been investigated as risk factors for dementia. However, previous investigations have yielded conflicting results...
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Anticholinergic Medications Linked to Risk of Dementia
July 22, 2019   

Dementia, especially of the Alzheimer type, is linked to severe loss of cholinergic neurons and the available treatments for Alzheimer's disease include several cholinesterase inhibitors, which increase available acetylcholine in the brain. However, there are several medications with...
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Remember to Sleep: Circadian Function in Alzheimer's Disease
July 2, 2019   

Alzheimer's disease affects approximately 44 million individuals worldwide. This age-related disease is characterized by accumulation of extracellular plaques composed of beta-amyloid protein, intracellular neurofibrillary tangles composed of hyperphosporylated tau protein, severe neuronal loss, and aggressive neuroinflammation. There is currently...
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Trials of Aducanumab in Alzheimer's Disease Are Being Discontinued
March 31, 2019   

Biogen and Eisai recently announced their decision to halt Phase 3 clinical trials, ENGAGE and EMERGE. The studies were originally designed to assess the efficacy and safety of aducanumab in patients with...
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