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Black Box Warnings: Implications for Clinical Practice, Antidepressants, and Suicide
Part 1: Neurobiology of Suicidality and Mechanisms of Antidepressant Medications
Overview: The podcast series titled “Black Box Warnings: Implications for Clinical Practice, Antidepressants, and Suicide” is divided into three parts. In Part 1, Drs. Sid Zisook and Stephen Stahl discuss what is currently known about the neurobiology underlying suicidality and mechanisms of action of antidepressants that may be related to that neurobiology.
Statement of Need: The following unmet need regarding suicide and antidepressants was revealed following a critical analysis of expert faculty assessment and literature review:
- As an abundance of research flooded the literature after the antidepressant black box warning regarding suicidality was issued, physicians need to re-evaluate what is currently known about the neurobiology of suicidality and how this may relate to the mechanisms of action of antidepressants
To help fill this unmet need, quality improvement efforts need to provide education regarding what is currently known about the neurobiology underlying suicidality and the potential relationship to antidepressant mechanisms of action.
Learning Objectives: After completing this activity, participants should be better able to fulfill the following learning objectives:
- Discuss what is known or hypothesized about the neurobiology underlying suicidality
- Identify mechanisms of antidepressants that may underlie side effects hypothesized to be associated with suicidality
Target Audience: This CME activity has been developed for MDs specializing in psychiatry. There are no prerequisites for this activity. Physicians in all specialties who are interested in psychopharmacology, as well as nurses, psychologists, and pharmacists, are welcome for advanced study.
Accreditation Statement: The Neuroscience Education Institute is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
Information on CME Credit: The Neuroscience Education Institute designates this educational activity for a maximum of 0.5 AMA PRA Category 1 CreditTM. Physicians should only claim credit commensurate with the extent of their participation in the activity. Also available will be a certificate of participation for completing this activity.
Activity Instructions: This CME activity is in the form of an MP3/Podcast. You are advised to listen to it from beginning to end, evaluate the content presented, and then complete the posttest and activity evaluation. There is no fee for this activity. The estimated time for completion of this activity is 30 minutes.
Instructions for CME Credit: To receive a certificate of CME credit or participation, please complete the posttest and evaluation available only online at www.neiglobal.com/cme. If a score of 70% or more is attained, you will be able to immediately print your certificate. If you have CME-related questions, please call 888-535-5600, or email customerservice@neiglobal.com.
NEI Disclosure Policy: It is the policy of the Neuroscience Education Institute to ensure balance, independence, objectivity, and scientific rigor in all its educational activities. Therefore, all individuals in a position to influence or control content development are required by NEI to disclose any financial relationships or apparent conflicts of interest. Although potential conflicts of interest are identified and resolved prior to the activity being presented, it remains for the participant to determine whether outside interests reflect a possible bias in either the exposition or the conclusions presented.
These materials have been peer-reviewed to ensure the scientific accuracy and medical relevance of information presented and its independence from commercial bias. The Neuroscience Education Institute takes responsibility for the content, quality, and scientific integrity of this CME activity.
Disclosure of Off-Label Use: This educational activity may include discussion of products or devices that are not currently labeled for such use by the FDA. Please consult the product prescribing information for full disclosure of labeled uses.
Disclaimer: The information presented in this educational activity is not meant to define a standard of care, nor is it intended to dictate an exclusive course of patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this educational activity should not be used by clinicians without full evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Primary references and full prescribing information should be consulted.
Participants have an implied responsibility to use the newly acquired information from this activity to enhance patient outcomes and their own professional development. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information, whether provided here or by others, for any professional use.
Individual Disclosure Statements: Full disclosures for all persons in a position to influence the content of this podcast are presented at the beginning of the podcast.
Disclosed financial relationships have been reviewed by the Neuroscience Education Institute CME Advisory Board to resolve any potential conflicts of interest. All faculty and planning committee members have attested that their financial relationships do not affect their ability to present well-balanced, evidence-based content for this activity.
Cultural and Linguistic Competency: With the passage of California Assembly Bill 1195, continuing medical education courses with patient care components are required to include curriculum in the subjects of cultural and linguistic competency. It is the intent of the bill, which went into effect on July 1, 2006, to encourage physicians, CME providers in the state of California, and the Accreditation Council for Continuing Medical Education to meet the cultural and linguistic concerns of a diverse patient population through appropriate professional development. The planners, speakers, and authors of this CME activity have been encouraged to address issues relevant to their topic area. In addition, a variety of resources addressing cultural and linguistic competency can be found in this linked handout.
| Sponsor: This activity is sponsored by Neuroscience Education Institute. |
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Support: This activity is supported by an educational grant from Lilly USA, LLC. For further information concerning Lilly grant funding visit, www.lillygrantoffice.com.
Date of Release/Expiration:
Release Date: August, 2009 CME Credit Expiration Date: July, 2012
System Requirements:
• Feed/media reader such as iTunes or Juice (free downloads)
• High speed Internet connection (e.g., Cable, DSL, or equivalent)
• Speakers connected to your computer and turned up
Use the link below to subscribe (free) to NEI's Sages of Psychopharmacology podcast, which includes this activity.
A podcast is a series of media files, such as audio or video, distributed over the Internet via a "web feed" for playback on portable media players (commonly MP3 players) and computers. A benefit of subscribing to a podcast is that as new podcast files are added to the series, they will automatically be downloaded for you.
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