Browsing articles in "Unipolar Depression"


UPDATE: New Guidelines Published for Diagnosis and Treatment of Depression in Adolescents in Primary Care
March 7, 2018   

Depression in children and adolescence is an enormous issue, especially given the potential risk for suicide in this young patient population. Unfortunately, in the primary care setting (which is where many patients are initially or solely seen by clinicians) as many as 2/3 of pediatric patients with depressive symptoms are not diagnosed...
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CYP2C19 Genotype Affects Escitalopram Exposure and Therapeutic Failure
February 2, 2018   

A new study shows that genotyping of CYP2C19 can help predict the therapeutic responsiveness to escitalopram and contribute to personalizing antidepressant therapy for the individual patient...
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First Clinical Trial of Intranasal Esketamine Shows Positive Results for Treatment-Resistant Depression
January 20, 2018   

A recent phase 2 clinical trial was conducted to assess the efficacy and safety of intranasal esketamine adjunctive to oral antidepressant therapy in treatment-resistant depression (TRD)...
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Nature vs. Nurture and the Risk of Depression
January 9, 2018   

A Swedish study finds genetics and environment equally contribute to major depression transmission. For the first time large-scale adoption study, researchers have found that the environment you’re raised in is as important as your genes in determining risk for major depression...
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Disappointing Results for Deep Brain Stimulation in Treatment-Resistant Depression
November 10, 2017   

A recent prospective RCT trial was conducted to test the safety and efficacy of deep brain stimulation (DBS) of the subcallosal cingulate white matter for treatment-resistant depression...
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Increased Risk of Type 2 Diabetes in Pediatric Patients Taking Antidepressants
November 1, 2017   

A newly published study found there an increased risk for youths to develop type 2 diabetes with current use of antidepressants. The antidepressant subclass, duration of antidepressant use, cumulative antidepressant dose, and average daily dose were...
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Perinatal Antidepressant Use and Psychiatric Disorders in Offspring
September 29, 2017   

A recent Danish cohort study examined the association between in utero exposure to antidepressants and risk of psychiatric disorders...
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New Mega-Analysis Supports Efficacy of Antidepressants in Adult Depression
September 12, 2017   

Recently, there has been much debate regarding the efficacy of antidepressants in the treatment of adults with major depressive disorder (MDD) due to the often-high levels of response to placebo in many clinical trials...
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SSRIs, SNRIs Show Small But Significant Benefit for Children and Adolescents With Common Mental Illnesses
September 11, 2017   

There continues to be much debate over the utility and risk-to-benefit ratio of antidepressant use within the pediatric population. In the present meta-analysis, Locher and colleagues investigated the safety and efficacy of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs)...
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Pediatric Suicide: Age Matters
June 20, 2017   

In the United States, the 4th leading cause of death among children age 5-14 years is suicide. In this study, Peyre and colleagues compared risk factors for suicide attempt in children and adolescents...
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