Browsing articles in "Alzheimer's/Other Dementias"


Pointing a Finger at Parkinson's Disease Dementia
January 12, 2018   

As many as 80% of patients with Parkinson's disease develop dementia (PDD)—a dementia that can be somewhat difficult to distinguish from Alzheimer's disease (AD). Appropriate diagnosis is key to planning as well as future application of disease-modifying treatments...
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Reducing Dementia Risk Through Lifestyle Changes: New Research
July 31, 2017   

In a newly published report by The Lancet Commission, the authors review the evidence for potentially modifiable factors that may help to reduce the risk of dementia...
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A Cross-Sectional Comparison of Brain Glucose and Ketone Metabolism in Cognitively Healthy Older Adults, Mild Cognitive Impairment (MCI) and Early Alzheimer’s Disease (AD)
July 19, 2017   

Deteriorating brain glucose metabolism precedes the clinical onset of AD and contributes to its etiology. Ketone bodies, mainly ß-hydroxybutyrate and acetoacetate are the primary alternative fuel to glucose. In a recent study...
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Merck Ends Trial of Alzheimer’s Medication
February 17, 2017   

Merck and Co Inc recently announced that they will halt a late-stage trial of the drug, verubescestat, developed to treat mild to moderate Alzheimer’s disease...
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Diagnostic Value of PET Imaging in Patients With Cognitive Impairment
December 16, 2016   

Advancements in neuroimaging over the past decade now allow us to use positron emission tomography (PET) coupled with amyloid-binding radiotracers to visualize Alzheimer's pathology in living brains. However, the utility of amyloid PET has been under much debate: does knowing that amyloid plaques are present in an individual's brain alter diagnosis or treatment?...
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Disappointing Results from Solanezumab Trial for Alzheimer's Disease
December 12, 2016   

Patients, families, caregivers, and researchers in the Alzheimer's Disease community suffered yet another disappointment this past month when Eli Lilly released data from its Phase 3 Expedition 3 trial of the anti-amyloid antibody, solanezumab...
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CerefolinNAC Therapy of Hyperhomocysteinemia Delays Cortical and White Matter Atrophy in Alzheimer’s Disease and Cerebrovascular Disease
December 3, 2016   

In a recent study, patients with Alzheimer’s disease (AD) or cognitive impairment due to cerebrovascular disease (CVD) were treated with a medical food therapy for hyperhomocysteinemia (HHcy)...
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Amyloid-Beta May Protect Against Infection
June 16, 2016   

Although amyloid-beta protein has been thoroughly researched as a key player in the neuropathology of Alzheimer's disease, its normal, physiological role has heretofore been unknown. In this extensive study by Kumar and colleagues, a wealth of data from transgenic mouse, nematode, and cell culture models are presented; collectively, these data suggest that amyloid-beta may serve an antimicrobial function designed to protect the brain from invading pathogens...
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American Psychiatric Association Practice Guideline for Use of Antipsychotics in Patients With Dementia
May 13, 2016   

At the December 2015 meeting, the American Psychiatric Association (APA) Board of Trustees approved the APA Practice Guideline Writing Group’s “Practice Guideline on Use of Antipsychotics to Treat Agitation or Psychosis in Patients with Dementia”. Within the guideline statements a “recommendation” (labeled with a numeral 1 after the statement) indicates confidence...
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Studies Identify Depression and Use of Anticholinergics as Risk Factors for Dementia
April 20, 2016   

Kaup et al. conducted a longitudinal study that followed nearly 2500 black and white older adults (mean age 74) for five years. Depressive symptom trajectories and cognitive impairment were assessed at multiple time points using standardized questionnaires. Having high and increasing depressive symptoms was associated with significantly increased risk for dementia...
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